Fate of Gold Nanoparticles in Laser Desorption/Ionization Mass Spectrometry
This article explains how a new technique called LDI MSI can show where nanoparticles are located on a surface. And of course, it happened with help of the correlative AFM-in-SEM measurements!
The correlative AFM-in-SEM imaging via LiteScope AFM-in-SEM helped again to identify the relevant regions of interest and quickly navigate the AFM tip there to perform local topography measurements. This time to map the spatial distribution of golden nanoparticles.
The article describes the testing o different ways how to prepare the nanoparticle samples and focuses on how the laser affected the individual nanoparticles. In conclusion, the LDI MSI technique is very good at detecting small numbers of them. However, it's important to make sure the right number of nanoparticles is put on the surface and to optimize the measurements. The researchers also used other techniques to look at the nanoparticles and found that some of them moved around when they were hit by the laser.
The LiteScope's added value has proved the ability to approach the individual golden nanoparticles and visualize their shape changes over the course of the experiment.